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Californian boffins find Elixir of Eternal Youth

Posted by keelynet on June 29, 2008

Closer and closer to longer life. With the world as screwed up as it is, wonder if such a discovery is a good idea?

“Mouse-molesting boffins in California have used biochemical signals to rejuvenate elderly, knackered bodily tissues in a fashion normally only achievable by youngsters. However, the scientists insist that they have not yet achieved an immortality drug, and if they had it would only be for mice. “We’re not at a point where we’re ready to inject ourselves with [this stuff]” said Dr Morgan Carlson. It seems that when we’re young, the stem cells in our bodies constantly repair and reinvigorate us. When we get old, this stops happening and pretty soon people are going through your stuff. “We don’t realize it, but as we grow our bodies are constantly being remodeled,” according to Conboy. “We are constantly falling apart, but we don’t notice it much when we’re young because we’re always being restored. As we age, our stem cells are prevented, through chemical signals, from doing their jobs.” Apparently one can revitalise stem cells by putting them in the right chemical environment. “When old tissue is placed in an environment of young blood, the stem cells behave as if they are young again,” according to the Berkeley press release – in a process not unlike that undergone by wrinkly old Hollywood stars placed in an environment of Catherine Zeta Jones.Essentially, the Californian researchers were able to persuade muscle tissues in some mice that they were young again. “We found that Notch is capable of physically kicking off pSmad3 from the promoters for the CDK inhibitors within the stem cell’s nucleus, which” – as any fool would realise – “tells us that a precise manipulation of the balance of these pathways would allow the ability to control stem cell responses.” Diddling with Notch and pSmad3 levels using “an established method of RNA interference” allowed Conboy and Carlson to manipulate TGF-beta proteins and fire up the dormant stem cells of a group of elderly mice. The octogenarian murines “showed levels of cellular regeneration that were comparable to their much younger peers”, apparently. But people shouldn’t just start swigging down Notch, pSmad3 and TGF-beta at random. Cellular regeneration, out of hand, is sometimes just another name for cancer. “We need to find out what the levels of these chemicals are in the young so we can calibrate the system when we’re older. If we can do that, we could rejuvenate tissue repair for a very long time.” – Source

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