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Root Cause of Epilepsy Found

Posted by keelynet on June 12, 2008

Wow, CO2? So that means by putting a bag over someones head when they are having an epileptic fit, they would breath the carbon dioxide back in and stop the fit? Amazing!

“Experiments in the last century found that by breathing carbon dioxide (CO²), an epileptic patient boosted acid levels in the brain and could terminate a fit, although the molecular switch for achieving this was veiled in mystery. In experiments on mice, scientists from the University of Iowa and the Veterans Affairs Iowa City Health Care System, reporting in a specialist journal, believe they have found the switch. A channel known as ASIC1a, located on the surface of brain cells, opens up in response to higher acid levels and admits charged atoms known as ions. This in turn activates other brain cells that block the seizures, the investigators believe. “We found that ASIC1a does not seem to play a role in how a seizure starts, but as the seizure continues and the pH is reduced, ASIC1a plays a role in stopping additional seizure activity,” said investigator Adam Ziemann. PH is a measure of acidity. The lower the pH index, the higher the acidity level. Among mice with ASIc1a, breathing CO² caused brain pH to drop rapidly and protect mice from lethal fits.” – Source

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