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10-Fold Life Extension in a Complex Animal

Posted by keelynet on February 12, 2008

Ah, to extend life, for what purpose? How many of us would put that extra time to good use? Would we use such a boon to help others or try to make the world a better place or simply pursue our own hedonistic pleasures?

“Researchers at the University of Arkansas for Medical Sciences (UAMS) have reported a 10-fold life extension in the complex animal C. elegans, tiny worms that live in the soil. Insulin alerts cells that there are nutrients in the blood ready to be used, whereas IGF-1 stimulates growth. Interfering with insulin signaling results in insulin resistance, a condition that can develop into diabetes. Interfering with IGF-1 signaling produces effects in mammals more akin to those seen in long-lived worms. Mice mildly deficient in IGF-1 receptor are long-lived and appear healthy, Reis said, adding that the longest-lived humans tend to have diminished IGF-1 signaling as well. “These observations hint that processes discovered in the worm also are relevant to aging in humans,” Reis said, “but we shouldn’t expect exact parallels.” Reis’ team discovered that a mutant in the insulin/ IGF-1 pathway of C. elegans slows development but ultimately produces adults he described as “super survivors,” able to resist levels of toxic chemicals that would kill an ordinary worm. Although the adult lifespan of C. elegans is normally only two to three weeks, half of the mutant worms were still alive after six months, with some surviving to nine months. “We knew we had found something amazing,” said Srinivas Ayyadevara, Ph.D., research assistant professor in the UAMS Donald W. Reynolds Institute on Aging. “These worms continue to look and act like normal worms of one-tenth their age.” – Source

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